Phenelzine and Bupropion Interaction
Drug interaction information between Phenelzine and Bupropion.
Phenelzine and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Phenelzine and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Phenelzine can make the harmful or toxic effects of bupropion much stronger and more dangerous to your body.
FDA Label Information
Studies in animals demonstrate that the acute toxicity of bupropion is enhanced by the MAO inhibitor phenelzine.
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Phenelzine + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Phenelzine's 27. In the minor band specifically: Phenelzine has 16 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine); Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Clopidogrel).
What mechanism field is on file for Phenelzine and Bupropion?
Phenelzine can make the harmful or toxic effects of bupropion much stronger and more dangerous to your body.
Bupropion carries more major-labeled pairs than Phenelzine
SPL source-record counts only. This page's band is minor · classes on file: Phenelzine (Monoamine Oxidase Inhibitor (MAOI)); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Bupropion has 1 major-labeled pair vs Phenelzine's 0. This page itself is in the minor band, not the major band.
0 major · 11 moderate · 16 minor · 27 total
- Other minor peers for Phenelzine
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.