Phenelzine and Buprenorphine/Naloxone Interaction
Drug interaction information between Phenelzine and Buprenorphine/Naloxone.
Phenelzine and Buprenorphine/Naloxone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Phenelzine and Buprenorphine/Naloxone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can cause a dangerous reaction that affects your brain's serotonin levels and can slow down your breathing.
FDA Label Information
Examples: phenelzine, tranylcypromine, linezolid Muscle Relaxants Clinical Impact: Buprenorphine may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression.
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
Buprenorphine/Naloxone Also Interacts With
- Gabapentin minor
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Pregabalin minor
Frequently Asked Questions
What SPL severity band is on file for Phenelzine + Buprenorphine/Naloxone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenelzine has 27 labeled pairs on file vs Buprenorphine/Naloxone's 19. In the minor band specifically: Phenelzine has 16 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine, Bupropion); Buprenorphine/Naloxone has 19 (also Gabapentin, Trazodone, Tramadol, Cyclobenzaprine).
What mechanism field is on file for Phenelzine and Buprenorphine/Naloxone?
This combination can cause a dangerous reaction that affects your brain's serotonin levels and can slow down your breathing.
Phenelzine's labeled portfolio outnumbers Buprenorphine/Naloxone
SPL source-record counts only. This page's band is minor · classes on file: Phenelzine (Monoamine Oxidase Inhibitor (MAOI)); Buprenorphine/Naloxone (Partial Opioid Agonist / Antagonist).
0 major · 11 moderate · 16 minor · 27 total
- Other minor peers for Phenelzine
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine
- Bupropion
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Buprenorphine/Naloxone
- Gabapentin
- Trazodone
- Tramadol
- Cyclobenzaprine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.