Phenelzine and Buprenorphine Interaction
Drug interaction information between Phenelzine and Buprenorphine.
Phenelzine and Buprenorphine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Phenelzine and Buprenorphine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs can interfere with each other, making the pain medicine less effective and potentially causing sudden withdrawal symptoms.
FDA Label Information
Examples: phenelzine, tranylcypromine, linezolid Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics Clinical Impact: May reduce the analgesic effect of BELBUCA and/or precipitate withdrawal symptoms.
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
Buprenorphine Also Interacts With
- Gabapentin minor
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Pregabalin minor
Frequently Asked Questions
What SPL severity band is on file for Phenelzine + Buprenorphine (Pain)?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenelzine has 27 labeled pairs on file vs Buprenorphine's 19. In the minor band specifically: Phenelzine has 16 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Bupropion); Buprenorphine has 19 (also Gabapentin, Trazodone, Tramadol, Cyclobenzaprine).
What mechanism field is on file for Phenelzine and Buprenorphine (Pain)?
These drugs can interfere with each other, making the pain medicine less effective and potentially causing sudden withdrawal symptoms.
Phenelzine's labeled portfolio outnumbers Buprenorphine
SPL source-record counts only. This page's band is minor · classes on file: Phenelzine (Monoamine Oxidase Inhibitor (MAOI)); Buprenorphine (Partial Opioid Agonist).
0 major · 11 moderate · 16 minor · 27 total
- Other minor peers for Phenelzine
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Bupropion
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Buprenorphine
- Gabapentin
- Trazodone
- Tramadol
- Cyclobenzaprine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.