Bupropion and Isavuconazonium Interaction
Drug interaction information between Bupropion and Isavuconazonium.
Bupropion and Isavuconazonium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Bupropion and Isavuconazonium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking isavuconazonium can lower the amount of bupropion in your system, making the medication less effective. This happens because the body clears the drug faster than normal.
FDA Label Information
Bupropion Use with Caution Concomitant administration of CRESEMBA and bupropion results in decrease in bupropion exposure. Dose increase of bupropion may be necessary when coadministered with CRESEMBA, but should not exceed the maximum recommended dose [see Clinical Pharmacology ( 12.3 )] .
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Metoprolol minor
- Sertraline minor
- Fluoxetine minor
Isavuconazonium Also Interacts With
- Itraconazole major
- Atorvastatin moderate
- Cyclosporine moderate
- Midazolam moderate
- Digoxin moderate
Frequently Asked Questions
What SPL severity band is on file for Bupropion + Isavuconazonium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Isavuconazonium's 9. In the moderate band specifically: Bupropion has 2 (also Theophylline); Isavuconazonium has 5 (also Atorvastatin, Cyclosporine, Midazolam, Digoxin).
What mechanism field is on file for Bupropion and Isavuconazonium?
Taking isavuconazonium can lower the amount of bupropion in your system, making the medication less effective. This happens because the body clears the drug faster than normal.
Bupropion's labeled portfolio outnumbers Isavuconazonium
SPL source-record counts only. This page's band is moderate · classes on file: Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)); Isavuconazonium (Azole Antifungal).
1 major · 2 moderate · 32 minor · 35 total
- Other moderate peers for Bupropion
- Theophylline
1 major · 5 moderate · 3 minor · 9 total
- Other moderate peers for Isavuconazonium
- Atorvastatin
- Cyclosporine
- Midazolam
- Digoxin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.