Phenelzine and Acetaminophen/Oxycodone Interaction
Drug interaction information between Phenelzine and Acetaminophen/Oxycodone.
Phenelzine and Acetaminophen/Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Phenelzine and Acetaminophen/Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together can cause a dangerous buildup of chemicals in the brain or lead to severe breathing problems. This combination can be life-threatening and may cause a condition called serotonin syndrome.
FDA Label Information
Monoamine Oxidase Inhibitors (MAOIs) The concomitant use of opioids and MAOIs, such as phenelzine, tranylcypromine, linezolid, may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma) [see WARNINGS ] .
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Frequently Asked Questions
What SPL severity band is on file for Phenelzine + Acetaminophen/Oxycodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenelzine has 27 labeled pairs on file vs Acetaminophen/Oxycodone's 23. In the minor band specifically: Phenelzine has 16 (also Buprenorphine, Buprenorphine/Naloxone, Buprenorphine, Bupropion); Acetaminophen/Oxycodone has 21 (also Trazodone, Tramadol, Cyclobenzaprine, Oxycodone).
What mechanism field is on file for Phenelzine and Acetaminophen/Oxycodone?
Taking these two drugs together can cause a dangerous buildup of chemicals in the brain or lead to severe breathing problems. This combination can be life-threatening and may cause a condition called serotonin syndrome.
Phenelzine's labeled portfolio outnumbers Acetaminophen/Oxycodone
SPL source-record counts only. This page's band is minor · classes on file: Phenelzine (Monoamine Oxidase Inhibitor (MAOI)); Acetaminophen/Oxycodone (Opioid Analgesic Combination).
0 major · 11 moderate · 16 minor · 27 total
- Other minor peers for Phenelzine
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
- Bupropion
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen/Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.