Bupropion and Sertraline Interaction
Drug interaction information between Bupropion and Sertraline.
Bupropion and Sertraline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bupropion and Sertraline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Bupropion slows down the process your liver uses to clear sertraline from your body. This can cause sertraline to build up in your system, increasing the risk of side effects.
FDA Label Information
( 7.1 ) Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide). Such drugs include certain antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, and sertraline), antipsychotics (e.g., haloperidol, risperidone, and thioridazine), beta-blockers...
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Fluoxetine minor
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Frequently Asked Questions
What SPL severity band is on file for Bupropion + Sertraline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Sertraline's 34. In the minor band specifically: Bupropion has 32 (also Metoprolol, Fluoxetine, Clopidogrel, Venlafaxine); Sertraline has 31 (also Fluoxetine, Citalopram, Paroxetine, Atenolol).
What mechanism field is on file for Bupropion and Sertraline?
Bupropion slows down the process your liver uses to clear sertraline from your body. This can cause sertraline to build up in your system, increasing the risk of side effects.
Bupropion's labeled portfolio outnumbers Sertraline
SPL source-record counts only. This page's band is minor · classes on file: Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)); Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)).
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Fluoxetine
- Clopidogrel
- Venlafaxine
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Citalopram
- Paroxetine
- Atenolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.