Phenelzine and Buprenorphine Interaction
Drug interaction information between Phenelzine and Buprenorphine.
Phenelzine and Buprenorphine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Phenelzine and Buprenorphine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs can cause a dangerous reaction that slows your breathing and affects your brain. It can also cause your blood pressure to change suddenly.
FDA Label Information
Examples: phenelzine, tranylcypromine, linezolid Muscle Relaxants Clinical Impact: Buprenorphine may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression.
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
Buprenorphine Also Interacts With
- Oxycodone moderate
- Trazodone minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Ketoconazole minor
Frequently Asked Questions
What SPL severity band is on file for Phenelzine + Buprenorphine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Buprenorphine has 29 labeled pairs on file vs Phenelzine's 27. In the minor band specifically: Phenelzine has 16 (also Acetaminophen/Oxycodone, Buprenorphine/Naloxone, Buprenorphine, Bupropion); Buprenorphine has 28 (also Trazodone, Cyclobenzaprine, Mirtazapine, Ketoconazole).
What mechanism field is on file for Phenelzine and Buprenorphine?
Combining these drugs can cause a dangerous reaction that slows your breathing and affects your brain. It can also cause your blood pressure to change suddenly.
Buprenorphine's labeled portfolio outnumbers Phenelzine
SPL source-record counts only. This page's band is minor · classes on file: Phenelzine (Monoamine Oxidase Inhibitor (MAOI)); Buprenorphine (Partial Opioid Agonist).
0 major · 11 moderate · 16 minor · 27 total
- Other minor peers for Phenelzine
- Acetaminophen/Oxycodone
- Buprenorphine/Naloxone
- Buprenorphine
- Bupropion
0 major · 1 moderate · 28 minor · 29 total
- Other minor peers for Buprenorphine
- Trazodone
- Cyclobenzaprine
- Mirtazapine
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.