Bupropion and Metoprolol Interaction
Drug interaction information between Bupropion and Metoprolol.
Bupropion and Metoprolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bupropion and Metoprolol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Bupropion blocks a liver enzyme that normally breaks down metoprolol. This causes the amount of metoprolol in your blood to rise to higher levels than expected.
What To Do
Your doctor may need to lower your dose of metoprolol. They should also check your heart rate and blood pressure more frequently.
FDA Label Information
( 7.1 ) Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide). Such drugs include certain antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, and sertraline), antipsychotics (e.g., haloperidol, risperidone, and thioridazine), beta-blockers...
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Sertraline minor
- Fluoxetine minor
Metoprolol Also Interacts With
- Theophylline major
- Clonidine moderate
- Diltiazem moderate
- Verapamil moderate
- Fluoxetine minor
Frequently Asked Questions
Can I take Bupropion and Metoprolol together?
This is a minor interaction. Your doctor may need to lower your dose of metoprolol. They should also check your heart rate and blood pressure more frequently.
How serious is the interaction between Bupropion and Metoprolol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Bupropion and Metoprolol interact?
Bupropion blocks a liver enzyme that normally breaks down metoprolol. This causes the amount of metoprolol in your blood to rise to higher levels than expected.
Understanding the Bupropion and Metoprolol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Bupropion belongs to the Norepinephrine-Dopamine Reuptake Inhibitor (NDRI) class and Metoprolol belongs to the Beta-Blocker class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Bupropion blocks a liver enzyme that normally breaks down metoprolol. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Bupropion has 35 total documented interactions on file in this dataset, and Metoprolol has 18. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to lower your dose of metoprolol. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Bupropion or Metoprolol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.