What the FDA labels say about taking them together
Bupropion and clopidogrel
Bupropion's FDA label of June 21, 2024 names clopidogrel in its drug interactions section; the clopidogrel label PlainMeds reads does not name bupropion. The bupropion label: “DRUG INTERACTIONS CYP2B6 Inhibitors: Ticlopidine or clopidogrel may increase bupropion exposure.”
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the clopidogrel FDA label on DailyMed (effective May 30, 2025, Sanofi-Aventis U.S. LLC).
What does the bupropion label say about clopidogrel?
Bupropion label, drug interactionsInhibitors of CYP2B6 Ticlopidine and Clopidogrel Concomitant treatment with these drugs can increase bupropion exposure but decrease hydroxybupropion exposure.
Bupropion Hcl Er (Xl) label (Lifestar Pharma LLC, February 4, 2026), drug interactionsDRUG INTERACTIONS CYP2B6 Inhibitors: Ticlopidine or clopidogrel may increase bupropion exposure.
Source: FDA drug label (Aplenzin, NDA022108), Bausch Health US, LLC, effective March 4, 2026 (SPL set 6494d2d9-0ce4-4126-b1c7-49684395942b), via openFDA
Source: FDA drug label (Bupropion Hcl Er (Xl), NDA022497), Lifestar Pharma LLC, effective February 4, 2026 (SPL set df959e1b-3f6d-42cf-8521-fe03b5a4ceb8), via openFDA
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the clopidogrel label say about bupropion?
Clopidogrel's label (effective May 30, 2025) does not name bupropion in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Plavix), Sanofi-Aventis U.S. LLC, effective May 30, 2025 (SPL set de8b0b67-eb25-4684-83b5-7ad785314227), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Clopidogrel | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | Heart attack and coronary artery disease, Angina |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | $0.0472 per tablet 75 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once