Phenelzine and Fluvoxamine Interaction
Drug interaction information between Phenelzine and Fluvoxamine.
Phenelzine and Fluvoxamine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Phenelzine and Fluvoxamine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase the amount of serotonin in your brain, which can cause a very dangerous and life-threatening reaction.
FDA Label Information
Drug Interactions In patients receiving nonselective monoamine oxidase (MAO) inhibitors in combination with serotoninergic agents (e.g., dexfenfluramine, fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, venlafaxine) there have been reports of serious, sometimes fatal, reactions.
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Desvenlafaxine moderate
Fluvoxamine Also Interacts With
- Tizanidine major
- Lithium moderate
- Tasimelteon moderate
- Metoprolol minor
- Omeprazole minor
Frequently Asked Questions
What SPL severity band is on file for Phenelzine + Fluvoxamine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluvoxamine has 40 labeled pairs on file vs Phenelzine's 27. In the moderate band specifically: Phenelzine has 11 (also Sertraline, Fluoxetine, Citalopram, Venlafaxine); Fluvoxamine has 3 (also Lithium, Tasimelteon).
What mechanism field is on file for Phenelzine and Fluvoxamine?
Both drugs increase the amount of serotonin in your brain, which can cause a very dangerous and life-threatening reaction.
Fluvoxamine carries more major-labeled pairs than Phenelzine
SPL source-record counts only. This page's band is moderate · classes on file: Phenelzine (Monoamine Oxidase Inhibitor (MAOI)); Fluvoxamine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluvoxamine has 1 major-labeled pair vs Phenelzine's 0. This page itself is in the moderate band, not the major band.
0 major · 11 moderate · 16 minor · 27 total
- Other moderate peers for Phenelzine
- Sertraline
- Fluoxetine
- Citalopram
- Venlafaxine
1 major · 3 moderate · 36 minor · 40 total
- Other moderate peers for Fluvoxamine
- Lithium
- Tasimelteon
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.