Phenelzine and Citalopram Interaction
Drug interaction information between Phenelzine and Citalopram.
Phenelzine and Citalopram have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Phenelzine and Citalopram. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs can cause too much serotonin to build up in your system. This can lead to very serious side effects that may be fatal.
FDA Label Information
Drug Interactions In patients receiving nonselective monoamine oxidase (MAO) inhibitors in combination with serotoninergic agents (e.g., dexfenfluramine, fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, venlafaxine) there have been reports of serious, sometimes fatal, reactions.
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Venlafaxine moderate
- Fluvoxamine moderate
- Desvenlafaxine moderate
Citalopram Also Interacts With
- Linezolid major
- Pimozide major
- Escitalopram major
- Warfarin moderate
- Buspirone minor
Frequently Asked Questions
What SPL severity band is on file for Phenelzine + Citalopram?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenelzine has 27 labeled pairs on file vs Citalopram's 9. In the moderate band specifically: Phenelzine has 11 (also Sertraline, Fluoxetine, Venlafaxine, Fluvoxamine); Citalopram has 2 (also Warfarin).
What mechanism field is on file for Phenelzine and Citalopram?
Combining these drugs can cause too much serotonin to build up in your system. This can lead to very serious side effects that may be fatal.
Citalopram carries more major-labeled pairs than Phenelzine
SPL source-record counts only. This page's band is moderate · classes on file: Phenelzine (Monoamine Oxidase Inhibitor (MAOI)); Citalopram (Selective Serotonin Reuptake Inhibitor (SSRI)).
Citalopram has 3 major-labeled pairs vs Phenelzine's 0. This page itself is in the moderate band, not the major band.
0 major · 11 moderate · 16 minor · 27 total
- Other moderate peers for Phenelzine
- Sertraline
- Fluoxetine
- Venlafaxine
- Fluvoxamine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.