Nicardipine and Naproxen Interaction
Drug interaction information between Nicardipine and Naproxen.
Nicardipine and Naproxen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nicardipine and Naproxen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Naproxen does not affect how nicardipine sticks to proteins in the blood.
FDA Label Information
When therapeutic concentrations of furosemide, propranolol, dipyridamole, warfarin, quinidine or naproxen were added to human plasma (in vitro), the plasma protein binding of nicardipine hydrochloride capsules were not altered.
Nicardipine Also Interacts With
- Digoxin major
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Furosemide minor
- Propranolol minor
Naproxen Also Interacts With
- Methotrexate moderate
- Magnesium Oxide moderate
- Diflunisal moderate
- Sucralfate moderate
- Cholestyramine moderate
Frequently Asked Questions
What SPL severity band is on file for Nicardipine + Naproxen?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Naproxen has 23 labeled pairs on file vs Nicardipine's 14. In the minor band specifically: Nicardipine has 11 (also Furosemide, Propranolol, Warfarin, Cyclosporine); Naproxen has 18 (also Meloxicam, Furosemide, Aspirin, Propranolol).
What mechanism field is on file for Nicardipine and Naproxen?
Naproxen does not affect how nicardipine sticks to proteins in the blood.
Nicardipine carries more major-labeled pairs than Naproxen
SPL source-record counts only. This page's band is minor · classes on file: Nicardipine (Calcium Channel Blocker); Naproxen (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
Nicardipine has 1 major-labeled pair vs Naproxen's 0. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 11 minor · 14 total
- Other minor peers for Nicardipine
- Furosemide
- Propranolol
- Warfarin
- Cyclosporine
0 major · 5 moderate · 18 minor · 23 total
- Other minor peers for Naproxen
- Meloxicam
- Furosemide
- Aspirin
- Propranolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.