Nicardipine and Tacrolimus Topical Interaction
Drug interaction information between Nicardipine and Tacrolimus Topical.
Nicardipine and Tacrolimus Topical have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Nicardipine and Tacrolimus Topical. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Nicardipine makes it harder for your body to process tacrolimus, which can cause the drug to stay in your system longer and reach higher levels. This increases the chance of experiencing dangerous side effects.
FDA Label Information
Mild or Moderate CYP3A Inhibitors: Clotrimazole, antibiotics (e.g., verapamil, diltiazem, nifedipine, nicardipine), amiodarone, danazol, ethinyl estradiol, cimetidine, lansoprazole and omeprazole May increase tacrolimus whole blood trough concentrations and increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation) [see Warnings and Precautions ( 5.7 , 5.10 , 5.11 )] .
Nicardipine Also Interacts With
- Digoxin major
- Nirmatrelvir/Ritonavir moderate
- Furosemide minor
- Propranolol minor
- Naproxen minor
Tacrolimus Topical Also Interacts With
- Omeprazole moderate
- Estradiol moderate
- Diltiazem moderate
- Nifedipine moderate
- Ketoconazole moderate
Frequently Asked Questions
What SPL severity band is on file for Nicardipine + Tacrolimus Topical?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tacrolimus Topical has 25 labeled pairs on file vs Nicardipine's 14. In the moderate band specifically: Nicardipine has 2 (also Nirmatrelvir/Ritonavir); Tacrolimus Topical has 19 (also Omeprazole, Estradiol, Diltiazem, Nifedipine).
What mechanism field is on file for Nicardipine and Tacrolimus Topical?
Nicardipine makes it harder for your body to process tacrolimus, which can cause the drug to stay in your system longer and reach higher levels. This increases the chance of experiencing dangerous side effects.
Nicardipine carries more major-labeled pairs than Tacrolimus Topical
SPL source-record counts only. This page's band is moderate · classes on file: Nicardipine (Calcium Channel Blocker); Tacrolimus Topical (Calcineurin Inhibitor (Topical)).
Nicardipine has 1 major-labeled pair vs Tacrolimus Topical's 0. This page itself is in the moderate band, not the major band.
1 major · 2 moderate · 11 minor · 14 total
- Other moderate peers for Nicardipine
- Nirmatrelvir/Ritonavir
0 major · 19 moderate · 6 minor · 25 total
- Other moderate peers for Tacrolimus Topical
- Omeprazole
- Estradiol
- Diltiazem
- Nifedipine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.