Naproxen and Propranolol Interaction
Drug interaction information between Naproxen and Propranolol.
Naproxen and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Naproxen and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Naproxen can make blood pressure medications like propranolol less effective at lowering your blood pressure.
FDA Label Information
ACE Inhibitors, Angiotensin Receptor Blockers, and Beta-Blockers Clinical Impact: • NSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol).
Naproxen Also Interacts With
- Methotrexate moderate
- Magnesium Oxide moderate
- Diflunisal moderate
- Sucralfate moderate
- Cholestyramine moderate
Frequently Asked Questions
What SPL severity band is on file for Naproxen + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Naproxen's 23. In the minor band specifically: Naproxen has 18 (also Meloxicam, Furosemide, Aspirin, Diclofenac); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Naproxen and Propranolol?
Naproxen can make blood pressure medications like propranolol less effective at lowering your blood pressure.
Propranolol's labeled portfolio outnumbers Naproxen
SPL source-record counts only. This page's band is minor · classes on file: Naproxen (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Propranolol (Non-Selective Beta-Blocker).
0 major · 5 moderate · 18 minor · 23 total
- Other minor peers for Naproxen
- Meloxicam
- Furosemide
- Aspirin
- Diclofenac
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.