Naproxen and Sucralfate Interaction
Drug interaction information between Naproxen and Sucralfate.
Naproxen and Sucralfate have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Naproxen and Sucralfate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sucralfate can slow down how quickly your body absorbs naproxen, which may delay its effects.
FDA Label Information
Antacids and Sucralfate Clinical Impact: Concomitant administration of some antacids (magnesium oxide or aluminum hydroxide) and sucralfate can delay the absorption of naproxen. Intervention: Concomitant administration of antacids such as magnesium oxide or aluminum hydroxide, and sucralfate with naproxen tablets and naproxen sodium tablets is not recommended.
Naproxen Also Interacts With
- Methotrexate moderate
- Magnesium Oxide moderate
- Diflunisal moderate
- Cholestyramine moderate
- Meloxicam minor
Sucralfate Also Interacts With
- Theophylline major
- Warfarin minor
- Ketoconazole minor
- Ciprofloxacin minor
- Ofloxacin minor
Frequently Asked Questions
What SPL severity band is on file for Naproxen + Sucralfate?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Naproxen has 23 labeled pairs on file vs Sucralfate's 20. In the moderate band specifically: Naproxen has 5 (also Methotrexate, Magnesium Oxide, Diflunisal, Cholestyramine); Sucralfate has 1.
What mechanism field is on file for Naproxen and Sucralfate?
Sucralfate can slow down how quickly your body absorbs naproxen, which may delay its effects.
Sucralfate carries more major-labeled pairs than Naproxen
SPL source-record counts only. This page's band is moderate · classes on file: Naproxen (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Sucralfate (Mucosal Protective Agent).
Sucralfate has 1 major-labeled pair vs Naproxen's 0. This page itself is in the moderate band, not the major band.
0 major · 5 moderate · 18 minor · 23 total
- Other moderate peers for Naproxen
- Methotrexate
- Magnesium Oxide
- Diflunisal
- Cholestyramine
1 major · 1 moderate · 18 minor · 20 total
Sucralfate has no other moderate-band peer in this dataset besides Naproxen.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.