What the FDA labels say about taking them together
Naproxen and sucralfate
Naproxen's FDA label of March 12, 2026 names sucralfate in its drug interactions (prescription label) section; the sucralfate labels PlainMeds reads (2) do not name naproxen.
Check it at the source: the naproxen FDA label on DailyMed (effective March 12, 2026, Bayer HealthCare LLC.); the sucralfate FDA label on DailyMed (effective September 2, 2026, Preferred Pharmaceuticals Inc.).
What does the naproxen label say about sucralfate?
Naproxen label, drug interactions (prescription label)Antacids and Sucralfate Clinical Impact: Concomitant administration of some antacids (…) and sucralfate can delay the absorption of naproxen. Intervention: Concomitant administration of antacids such as magnesium oxide or aluminum hydroxide, and sucralfate with naproxen tablets and naproxen sodium tablets is not recommended.
Source: FDA drug label (Naprelan, NDA020353), Upsher-Smith Laboratories, LLC, effective January 8, 2026 (SPL set b8a51c9a-488e-4377-a041-436f6a2f8893), via openFDA
Source: FDA drug label (Aleve Caplets), Bayer HealthCare LLC., effective March 12, 2026 (SPL set 02941928-128a-2c88-e063-6294a90ac6ba), via openFDA; the full label on DailyMed
What does the sucralfate label say about naproxen?
Sucralfate's label (effective September 2, 2026) and its 1 other brand-application label do not name naproxen in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Sucralfate), NDA018333 (Abbvie), as published by Preferred Pharmaceuticals Inc., effective September 2, 2026 (SPL set 536b8c00-13ab-4397-a754-63a1c92bf883), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Naproxen | Sucralfate | |
|---|---|---|
| Labeled for | Fever, Rheumatoid arthritis, Osteoarthritis, Gout, Pain, Cough and cold | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0565 per tablet 500 mg tablet | $0.173 per tablet 1 g tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once