Naproxen and Aspirin Interaction
Drug interaction information between Naproxen and Aspirin.
Naproxen and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Naproxen and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Naproxen can stop aspirin from working correctly to protect your heart and also increases the chance of stomach bleeding. Taking them together makes it harder for your blood to clot when it needs to.
FDA Label Information
Intervention: Monitor patients with concomitant use of naproxen tablets or naproxen sodium tablets with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., aspirin), selective serotonin reuptake inhibitors (SSRIs), and serotonin norepinephrine reuptake inhibitors (SNRIs) for signs of bleeding [ see Warnings and Precautions ( 5.12 ) ]. Aspirin Clinical Impact: A pharmacodynamic (PD) study has demonstrated an interaction in which lower dose naproxen (220mg/day or 220mg twice daily) interfered with the antiplatelet effect of low-dose immediate-release aspirin, with the interaction...
Naproxen Also Interacts With
- Methotrexate moderate
- Magnesium Oxide moderate
- Diflunisal moderate
- Sucralfate moderate
- Cholestyramine moderate
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Naproxen + Aspirin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Naproxen's 23. In the minor band specifically: Naproxen has 18 (also Meloxicam, Furosemide, Propranolol, Diclofenac); Aspirin has 32 (also Carisoprodol, Celecoxib, Colestipol, Diflunisal).
What mechanism field is on file for Naproxen and Aspirin?
Naproxen can stop aspirin from working correctly to protect your heart and also increases the chance of stomach bleeding. Taking them together makes it harder for your blood to clot when it needs to.
Aspirin carries more major-labeled pairs than Naproxen
SPL source-record counts only. This page's band is minor · classes on file: Naproxen (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Naproxen's 0. This page itself is in the minor band, not the major band.
0 major · 5 moderate · 18 minor · 23 total
- Other minor peers for Naproxen
- Meloxicam
- Furosemide
- Propranolol
- Diclofenac
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Celecoxib
- Colestipol
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.