Nicardipine and Cyclosporine Interaction
Drug interaction information between Nicardipine and Cyclosporine.
Nicardipine and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nicardipine and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Nicardipine blocks the liver's ability to break down cyclosporine, which can lead to high levels of cyclosporine in the body.
FDA Label Information
Cyclosporine Concomitant administration of oral or intravenous nicardipine and cyclosporine results in elevated plasma cyclosporine levels though nicardipine inhibition of hepatic microsomal enzymes, including CYP3A4. Plasma concentrations of cyclosporine should therefore be closely monitored, and its dosage reduced accordingly, in patients treated with nicardipine.
Nicardipine Also Interacts With
- Digoxin major
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Furosemide minor
- Propranolol minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Nicardipine + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Nicardipine's 14. In the minor band specifically: Nicardipine has 11 (also Furosemide, Propranolol, Naproxen, Warfarin); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Nicardipine and Cyclosporine?
Nicardipine blocks the liver's ability to break down cyclosporine, which can lead to high levels of cyclosporine in the body.
Cyclosporine carries more major-labeled pairs than Nicardipine
SPL source-record counts only. This page's band is minor · classes on file: Nicardipine (Calcium Channel Blocker); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Nicardipine's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 11 minor · 14 total
- Other minor peers for Nicardipine
- Furosemide
- Propranolol
- Naproxen
- Warfarin
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.