naproxen vs nicardipine
Side-by-side comparison of naproxen and nicardipine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
When therapeutic concentrations of furosemide, propranolol, dipyridamole, warfarin, quinidine or naproxen were added to human plasma (in vitro), the plasma protein binding of nicardipine hydrochloride capsules were not altered.
Recommendation: No special precautions or dose changes are required for this combination.
Aleve, Naprosyn
Cardene
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). It helps reduce pain, swelling, and stiffness.
Nicardipine is a drug that helps to lower blood pressure and treat chest pain. It belongs to a class of drugs called calcium channel blockers.
Naproxen is used to relieve pain and inflammation. You can use it for arthritis, including rheumatoid arthritis and osteoarthritis. It also treats ankylosing spondylitis and juvenile idiopathic arthritis. Naproxen can help with tendonitis, bursitis, gout, menstrual cramps, and general pain.
Nicardipine treats chronic stable angina, which is chest pain that happens when you exert yourself. It can be used alone or with beta-blockers to manage this condition. Nicardipine also treats high blood pressure, and it can be used alone or with other blood pressure medications.
Naproxen works by reducing substances in the body that cause pain and inflammation. It blocks the production of prostaglandins. These substances contribute to the symptoms of pain, swelling, and fever.
Nicardipine works by blocking calcium from entering certain cells in your heart and blood vessels. This helps to relax and widen your blood vessels, which lowers blood pressure. It also reduces the workload on your heart, which can help to relieve chest pain.
- • Heartburn
- • Abdominal pain
- • Nausea
- • Constipation
- • Diarrhea
- • Swelling in your feet or ankles
- • Dizziness
- • Headache
- • Weakness
- • Flushing (redness of the skin)
- Pain 8,756
- Tiredness 7,338
- Joint pain 7,244
- Feeling sick to your stomach 7,063
- Headache 5,717
- Sudden kidney damage 226
- Baby born too early 205
- Unborn baby exposed to the drug during pregnancy 194
- Mother exposed to the drug during pregnancy 180
- The drug is interacting with another drug 167
Naproxen may increase your risk of serious heart problems like heart attack or stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take naproxen if you are having heart bypass surgery. Naproxen can also increase your risk of serious stomach and intestine problems, including bleeding, ulcers, and holes, which can be fatal. These problems can occur without warning. Elderly people are at higher risk.
If you have advanced aortic stenosis, you should not take this medication. Lowering blood pressure in this case could worsen oxygen balance to the heart. Use caution if you have congestive heart failure.
Using naproxen after 20 weeks of pregnancy can cause kidney problems in the unborn baby, leading to low amniotic fluid. Avoid using naproxen at 30 weeks of pregnancy or later because it can cause the baby's heart to close too early. Talk to your doctor if you are pregnant or plan to become pregnant.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if nicardipine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking nicardipine during pregnancy or while breastfeeding.
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How to Read This naproxen vs nicardipine Comparison
naproxen is classified in the Nonsteroidal Anti-Inflammatory Drug (NSAID) drug class, while nicardipine sits within the Calcium Channel Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, naproxen has 36,118 submissions while nicardipine has 972. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to naproxen does not affect how nicardipine sticks to proteins in the blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between naproxen and nicardipine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.