Nicardipine and Propranolol Interaction
Drug interaction information between Nicardipine and Propranolol.
Nicardipine and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nicardipine and Propranolol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Propranolol does not change the way nicardipine binds to proteins in your bloodstream.
What To Do
You can typically take these two drugs together without needing a dose adjustment.
FDA Label Information
When therapeutic concentrations of furosemide, propranolol, dipyridamole, warfarin, quinidine or naproxen were added to human plasma (in vitro), the plasma protein binding of nicardipine hydrochloride capsules were not altered.
Nicardipine Also Interacts With
- Digoxin major
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Furosemide minor
- Naproxen minor
Frequently Asked Questions
Can I take Nicardipine and Propranolol together?
This is a minor interaction. You can typically take these two drugs together without needing a dose adjustment.
How serious is the interaction between Nicardipine and Propranolol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Nicardipine and Propranolol interact?
Propranolol does not change the way nicardipine binds to proteins in your bloodstream.
Understanding the Nicardipine and Propranolol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Nicardipine belongs to the Calcium Channel Blocker class and Propranolol belongs to the Non-Selective Beta-Blocker class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Propranolol does not change the way nicardipine binds to proteins in your bloodstream. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Nicardipine has 14 total documented interactions on file in this dataset, and Propranolol has 44. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can typically take these two drugs together without needing a dose adjustment. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Nicardipine or Propranolol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.