Nicardipine and Propranolol Interaction
Drug interaction information between Nicardipine and Propranolol.
Nicardipine and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nicardipine and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Propranolol does not change the way nicardipine binds to proteins in your bloodstream.
FDA Label Information
When therapeutic concentrations of furosemide, propranolol, dipyridamole, warfarin, quinidine or naproxen were added to human plasma (in vitro), the plasma protein binding of nicardipine hydrochloride capsules were not altered.
Nicardipine Also Interacts With
- Digoxin major
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Furosemide minor
- Naproxen minor
Frequently Asked Questions
What SPL severity band is on file for Nicardipine + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Nicardipine's 14. In the minor band specifically: Nicardipine has 11 (also Furosemide, Naproxen, Warfarin, Cyclosporine); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Nicardipine and Propranolol?
Propranolol does not change the way nicardipine binds to proteins in your bloodstream.
Nicardipine carries more major-labeled pairs than Propranolol
SPL source-record counts only. This page's band is minor · classes on file: Nicardipine (Calcium Channel Blocker); Propranolol (Non-Selective Beta-Blocker).
Nicardipine has 1 major-labeled pair vs Propranolol's 0. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 11 minor · 14 total
- Other minor peers for Nicardipine
- Furosemide
- Naproxen
- Warfarin
- Cyclosporine
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.