What the FDA labels say about taking them together
Magnesium oxide and naproxen
Naproxen's FDA label of March 12, 2026 names magnesium oxide in its drug interactions (prescription label) section; the magnesium oxide label PlainMeds reads does not name naproxen.
Check it at the source: the magnesium oxide FDA label on DailyMed (effective July 6, 2026); the naproxen FDA label on DailyMed (effective March 12, 2026, Bayer HealthCare LLC.).
What does the magnesium oxide label say about naproxen?
Magnesium oxide's label (effective July 6, 2026) does not name naproxen in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Magnesium Oxide), Westminster Pharmaceuticals, LLC, effective July 6, 2026 (SPL set 52eeac0e-94bb-48c3-81dc-578e96406c01), via openFDA; the full label on DailyMed
What does the naproxen label say about magnesium oxide?
Naproxen label, drug interactions (prescription label)Clinical Impact: Concomitant administration of some antacids (…) and sucralfate can delay the absorption of naproxen. Intervention: Concomitant administration of antacids such as magnesium oxide or aluminum hydroxide, and sucralfate with naproxen tablets and naproxen sodium tablets is not recommended.
Source: FDA drug label (Naprelan, NDA020353), Upsher-Smith Laboratories, LLC, effective January 8, 2026 (SPL set b8a51c9a-488e-4377-a041-436f6a2f8893), via openFDA
Source: FDA drug label (Naproxen, NDA018965), Acella Pharmaceuticals, LLC, effective January 5, 2026 (SPL set 7e6f03fb-4b36-4418-9684-f45637abbb78), via openFDA
Source: FDA drug label (Naproxen, NDA020067), Zameer Pharmaceuticals LLC, effective August 23, 2025 (SPL set d2e5553a-7c90-407c-9f07-3be65560c23a), via openFDA
Source: FDA drug label (Aleve Caplets), Bayer HealthCare LLC., effective March 12, 2026 (SPL set 02941928-128a-2c88-e063-6294a90ac6ba), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Magnesium oxide | Naproxen | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Fever, Rheumatoid arthritis, Osteoarthritis, Gout, Pain, Cough and cold |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0346 per tablet 400 mg tablet | $0.0565 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once