Naproxen and Magnesium Oxide Interaction
Drug interaction information between Naproxen and Magnesium Oxide.
Naproxen and Magnesium Oxide have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Naproxen and Magnesium Oxide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Magnesium oxide can slow down how quickly your body absorbs naproxen into your bloodstream. This might make the naproxen take longer to start working.
FDA Label Information
Antacids and Sucralfate Clinical Impact: Concomitant administration of some antacids (magnesium oxide or aluminum hydroxide) and sucralfate can delay the absorption of naproxen. Intervention: Concomitant administration of antacids such as magnesium oxide or aluminum hydroxide, and sucralfate with naproxen tablets and naproxen sodium tablets is not recommended.
Naproxen Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Sucralfate moderate
- Cholestyramine moderate
- Meloxicam minor
Frequently Asked Questions
What SPL severity band is on file for Naproxen + Magnesium Oxide?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Naproxen has 23 labeled pairs on file vs Magnesium Oxide's 1. In the moderate band specifically: Naproxen has 5 (also Methotrexate, Diflunisal, Sucralfate, Cholestyramine); Magnesium Oxide has 1.
What mechanism field is on file for Naproxen and Magnesium Oxide?
Magnesium oxide can slow down how quickly your body absorbs naproxen into your bloodstream. This might make the naproxen take longer to start working.
Naproxen's labeled portfolio outnumbers Magnesium Oxide
SPL source-record counts only. This page's band is moderate · classes on file: Naproxen (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Magnesium Oxide (Mineral Supplement).
0 major · 5 moderate · 18 minor · 23 total
- Other moderate peers for Naproxen
- Methotrexate
- Diflunisal
- Sucralfate
- Cholestyramine
0 major · 1 moderate · 0 minor · 1 total
Magnesium Oxide has no other moderate-band peer in this dataset besides Naproxen.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.