Naproxen and Meloxicam Interaction
Drug interaction information between Naproxen and Meloxicam.
Naproxen and Meloxicam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Naproxen and Meloxicam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs are in the same family of pain relievers, and taking them together increases the risk of serious side effects like stomach bleeding. Using multiple drugs of this type can also be hard on the kidneys.
FDA Label Information
In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives (e.g., meloxicam, nabumetone), patients taking these NSAIDs should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration.
Naproxen Also Interacts With
- Methotrexate moderate
- Magnesium Oxide moderate
- Diflunisal moderate
- Sucralfate moderate
- Cholestyramine moderate
Meloxicam Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
Frequently Asked Questions
What SPL severity band is on file for Naproxen + Meloxicam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Naproxen has 23 labeled pairs on file vs Meloxicam's 17. In the minor band specifically: Naproxen has 18 (also Furosemide, Aspirin, Propranolol, Diclofenac); Meloxicam has 15 (also Furosemide, Aspirin, Propranolol, Warfarin).
What mechanism field is on file for Naproxen and Meloxicam?
Both drugs are in the same family of pain relievers, and taking them together increases the risk of serious side effects like stomach bleeding. Using multiple drugs of this type can also be hard on the kidneys.
Naproxen's labeled portfolio outnumbers Meloxicam
SPL source-record counts only. This page's band is minor · classes on file: Naproxen (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Meloxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 5 moderate · 18 minor · 23 total
- Other minor peers for Naproxen
- Furosemide
- Aspirin
- Propranolol
- Diclofenac
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Meloxicam
- Furosemide
- Aspirin
- Propranolol
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.