Naproxen and Meloxicam Interaction
Drug interaction information between Naproxen and Meloxicam.
Naproxen and Meloxicam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Naproxen and Meloxicam. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs are in the same family of pain relievers, and taking them together increases the risk of serious side effects like stomach bleeding. Using multiple drugs of this type can also be hard on the kidneys.
What To Do
Avoid taking these two medications together. Talk to your doctor about using a different combination for pain relief.
FDA Label Information
In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives (e.g., meloxicam, nabumetone), patients taking these NSAIDs should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration.
Naproxen Also Interacts With
- Methotrexate moderate
- Magnesium Oxide moderate
- Diflunisal moderate
- Sucralfate moderate
- Cholestyramine moderate
Meloxicam Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
Frequently Asked Questions
Can I take Naproxen and Meloxicam together?
This is a minor interaction. Avoid taking these two medications together. Talk to your doctor about using a different combination for pain relief.
How serious is the interaction between Naproxen and Meloxicam?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Naproxen and Meloxicam interact?
Both drugs are in the same family of pain relievers, and taking them together increases the risk of serious side effects like stomach bleeding. Using multiple drugs of this type can also be hard on the kidneys.
Understanding the Naproxen and Meloxicam Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Naproxen belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class and Meloxicam belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs are in the same family of pain relievers, and taking them together increases the risk of serious side effects like stomach bleeding. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Naproxen has 23 total documented interactions on file in this dataset, and Meloxicam has 17. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid taking these two medications together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Naproxen or Meloxicam based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.