Nicardipine and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Nicardipine and Nirmatrelvir/Ritonavir.
Nicardipine and Nirmatrelvir/Ritonavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Nicardipine and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ritonavir blocks the way your body processes nicardipine, which can cause the blood pressure medicine to reach higher levels than intended.
FDA Label Information
Calcium channel blockers amlodipine, diltiazem, felodipine, nicardipine, nifedipine, verapamil ↑ calcium channel blocker Caution is warranted and clinical monitoring of patients is recommended.
Nicardipine Also Interacts With
- Digoxin major
- Tacrolimus Topical moderate
- Furosemide minor
- Propranolol minor
- Naproxen minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Nicardipine + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Nicardipine's 14. In the moderate band specifically: Nicardipine has 2 (also Tacrolimus Topical); Nirmatrelvir/Ritonavir has 30 (also Amlodipine, Tamsulosin, Fluticasone, Apixaban).
What mechanism field is on file for Nicardipine and Nirmatrelvir/Ritonavir?
Ritonavir blocks the way your body processes nicardipine, which can cause the blood pressure medicine to reach higher levels than intended.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Nicardipine
SPL source-record counts only. This page's band is moderate · classes on file: Nicardipine (Calcium Channel Blocker); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Nicardipine's 1. This page itself is in the moderate band, not the major band.
1 major · 2 moderate · 11 minor · 14 total
- Other moderate peers for Nicardipine
- Tacrolimus Topical
23 major · 30 moderate · 33 minor · 86 total
- Other moderate peers for Nirmatrelvir/Ritonavir
- Amlodipine
- Tamsulosin
- Fluticasone
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.