Naproxen and Cholestyramine Interaction
Drug interaction information between Naproxen and Cholestyramine.
Naproxen and Cholestyramine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Naproxen and Cholestyramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cholestyramine can slow down the absorption of naproxen into your system.
FDA Label Information
Cholestyramine Clinical Impact: Concomitant administration of cholestyramine can delay the absorption of naproxen. Intervention: Concomitant administration of cholestyramine with naproxen tablets or naproxen sodium tablets is not recommended.
Naproxen Also Interacts With
- Methotrexate moderate
- Magnesium Oxide moderate
- Diflunisal moderate
- Sucralfate moderate
- Meloxicam minor
Cholestyramine Also Interacts With
- Olmesartan moderate
- Raloxifene moderate
- Propranolol minor
- Warfarin minor
- Tetracycline minor
Frequently Asked Questions
What SPL severity band is on file for Naproxen + Cholestyramine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cholestyramine has 34 labeled pairs on file vs Naproxen's 23. In the moderate band specifically: Naproxen has 5 (also Methotrexate, Magnesium Oxide, Diflunisal, Sucralfate); Cholestyramine has 3 (also Olmesartan, Raloxifene).
What mechanism field is on file for Naproxen and Cholestyramine?
Cholestyramine can slow down the absorption of naproxen into your system.
Cholestyramine's labeled portfolio outnumbers Naproxen
SPL source-record counts only. This page's band is moderate · classes on file: Naproxen (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Cholestyramine (Bile Acid Sequestrant).
0 major · 5 moderate · 18 minor · 23 total
- Other moderate peers for Naproxen
- Methotrexate
- Magnesium Oxide
- Diflunisal
- Sucralfate
0 major · 3 moderate · 31 minor · 34 total
- Other moderate peers for Cholestyramine
- Olmesartan
- Raloxifene
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.