Mirtazapine and Carbamazepine Interaction
Drug interaction information between Mirtazapine and Carbamazepine.
Mirtazapine and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Mirtazapine and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This drug slows down how your body breaks down mirtazapine, which can cause the medicine to build up in your blood.
FDA Label Information
Examples phenytoin, carbamazepine, rifampin Strong CYP3A Inhibitors Clinical Impact The concomitant use of strong CYP3A inhibitors with mirtazapine may increase the plasma concentration of mirtazapine [see Clinical Pharmacology (12.3) ].
Mirtazapine Also Interacts With
- Linezolid major
- Alprazolam moderate
- Diazepam moderate
- Phenelzine moderate
- Tranylcypromine moderate
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Mirtazapine + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Mirtazapine's 29. In the minor band specifically: Mirtazapine has 23 (also Buspirone, Warfarin, Lithium, Rifampin); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Mirtazapine and Carbamazepine?
This drug slows down how your body breaks down mirtazapine, which can cause the medicine to build up in your blood.
Carbamazepine carries more major-labeled pairs than Mirtazapine
SPL source-record counts only. This page's band is minor · classes on file: Mirtazapine (Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Mirtazapine's 1. This page itself is in the minor band, not the major band.
1 major · 5 moderate · 23 minor · 29 total
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.