Mirtazapine and Buspirone Interaction
Drug interaction information between Mirtazapine and Buspirone.
Mirtazapine and Buspirone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Mirtazapine and Buspirone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these drugs together can cause the body to clear mirtazapine faster, which lowers the amount of medicine in your blood.
FDA Label Information
John’s Wort, tramadol, tryptophan, buspirone Strong CYP3A Inducers Clinical Impact The concomitant use of strong CYP3A inducers with mirtazapine decreases the plasma concentration of mirtazapine [see Clinical Pharmacology (12.3) ].
Mirtazapine Also Interacts With
- Linezolid major
- Alprazolam moderate
- Diazepam moderate
- Phenelzine moderate
- Tranylcypromine moderate
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
Frequently Asked Questions
What SPL severity band is on file for Mirtazapine + Buspirone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Mirtazapine has 29 labeled pairs on file vs Buspirone's 17. In the minor band specifically: Mirtazapine has 23 (also Warfarin, Carbamazepine, Lithium, Rifampin); Buspirone has 15 (also Citalopram, Darunavir, Desvenlafaxine, Diltiazem).
What mechanism field is on file for Mirtazapine and Buspirone?
Using these drugs together can cause the body to clear mirtazapine faster, which lowers the amount of medicine in your blood.
Mirtazapine carries more major-labeled pairs than Buspirone
SPL source-record counts only. This page's band is minor · classes on file: Mirtazapine (Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)); Buspirone (Azapirone Anxiolytic).
Mirtazapine has 1 major-labeled pair vs Buspirone's 0. This page itself is in the minor band, not the major band.
1 major · 5 moderate · 23 minor · 29 total
- Other minor peers for Mirtazapine
- Warfarin
- Carbamazepine
- Lithium
- Rifampin
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Citalopram
- Darunavir
- Desvenlafaxine
- Diltiazem
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.