Mirtazapine and Lithium Interaction
Drug interaction information between Mirtazapine and Lithium.
Mirtazapine and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Mirtazapine and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines increase a brain chemical called serotonin, and taking them together can cause levels to become too high.
FDA Label Information
Examples SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, lithium, amphetamines, St.
Mirtazapine Also Interacts With
- Linezolid major
- Alprazolam moderate
- Diazepam moderate
- Phenelzine moderate
- Tranylcypromine moderate
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Mirtazapine + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Mirtazapine's 29. In the minor band specifically: Mirtazapine has 23 (also Buspirone, Warfarin, Carbamazepine, Rifampin); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Mirtazapine and Lithium?
Both of these medicines increase a brain chemical called serotonin, and taking them together can cause levels to become too high.
Lithium carries more major-labeled pairs than Mirtazapine
SPL source-record counts only. This page's band is minor · classes on file: Mirtazapine (Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Mirtazapine's 1. This page itself is in the minor band, not the major band.
1 major · 5 moderate · 23 minor · 29 total
- Other minor peers for Mirtazapine
- Buspirone
- Warfarin
- Carbamazepine
- Rifampin
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.