Mirtazapine and Alprazolam Interaction
Drug interaction information between Mirtazapine and Alprazolam.
Mirtazapine and Alprazolam have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Mirtazapine and Alprazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together can change the electrical timing of your heartbeat. This increases the risk of developing a dangerous irregular heart rhythm.
FDA Label Information
Examples diazepam, alprazolam, alcohol Drugs that Prolong QTc Interval Clinical Impact The concomitant use of other drugs which prolong the QTc interval with mirtazapine, increase the risk of QTc prolongation and/or ventricular arrhythmias (e.g., Torsades de Pointes).
Mirtazapine Also Interacts With
- Linezolid major
- Diazepam moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
Frequently Asked Questions
What SPL severity band is on file for Mirtazapine + Alprazolam?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Mirtazapine has 29 labeled pairs on file vs Alprazolam's 27. In the moderate band specifically: Mirtazapine has 5 (also Diazepam, Phenelzine, Tranylcypromine, Selegiline); Alprazolam has 7 (also Ketoconazole, Clarithromycin, Itraconazole, Digoxin).
What mechanism field is on file for Mirtazapine and Alprazolam?
Taking these two drugs together can change the electrical timing of your heartbeat. This increases the risk of developing a dangerous irregular heart rhythm.
Mirtazapine carries more major-labeled pairs than Alprazolam
SPL source-record counts only. This page's band is moderate · classes on file: Mirtazapine (Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)); Alprazolam (Benzodiazepine).
Mirtazapine has 1 major-labeled pair vs Alprazolam's 0. This page itself is in the moderate band, not the major band.
1 major · 5 moderate · 23 minor · 29 total
- Other moderate peers for Mirtazapine
- Diazepam
- Phenelzine
- Tranylcypromine
- Selegiline
0 major · 7 moderate · 20 minor · 27 total
- Other moderate peers for Alprazolam
- Ketoconazole
- Clarithromycin
- Itraconazole
- Digoxin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.