Mirtazapine and Rifampin Interaction
Drug interaction information between Mirtazapine and Rifampin.
Mirtazapine and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Mirtazapine and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medication interferes with the way your body clears mirtazapine, leading to higher levels of the drug in your system.
FDA Label Information
Examples phenytoin, carbamazepine, rifampin Strong CYP3A Inhibitors Clinical Impact The concomitant use of strong CYP3A inhibitors with mirtazapine may increase the plasma concentration of mirtazapine [see Clinical Pharmacology (12.3) ].
Mirtazapine Also Interacts With
- Linezolid major
- Alprazolam moderate
- Diazepam moderate
- Phenelzine moderate
- Tranylcypromine moderate
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Mirtazapine + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Mirtazapine's 29. In the minor band specifically: Mirtazapine has 23 (also Buspirone, Warfarin, Carbamazepine, Lithium); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Mirtazapine and Rifampin?
This medication interferes with the way your body clears mirtazapine, leading to higher levels of the drug in your system.
Rifampin carries more major-labeled pairs than Mirtazapine
SPL source-record counts only. This page's band is minor · classes on file: Mirtazapine (Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Mirtazapine's 1. This page itself is in the minor band, not the major band.
1 major · 5 moderate · 23 minor · 29 total
- Other minor peers for Mirtazapine
- Buspirone
- Warfarin
- Carbamazepine
- Lithium
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.