Carbamazepine and Apixaban Interaction
Drug interaction information between Carbamazepine and Apixaban.
Carbamazepine and Apixaban have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Carbamazepine and Apixaban. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine makes your body break down apixaban too fast, which lowers the drug levels in your blood. This makes the medicine less effective at preventing dangerous blood clots.
FDA Label Information
7.2 Combined P-gp Strong CYP3A4 Inducers Avoid concomitant use of apixaban tablets with combined P-gp and strong CYP3A4 Inducers (e.g., rifampin, carbamazepine, phenytoin, St.
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Desmopressin moderate
Apixaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Warfarin moderate
- Rifampin moderate
- Heparin moderate
Frequently Asked Questions
What SPL severity band is on file for Carbamazepine + Apixaban?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Apixaban's 12. In the moderate band specifically: Carbamazepine has 16 (also Lithium, Desmopressin, Dronedarone, Fluconazole); Apixaban has 9 (also Clopidogrel, Aspirin, Warfarin, Rifampin).
What mechanism field is on file for Carbamazepine and Apixaban?
Carbamazepine makes your body break down apixaban too fast, which lowers the drug levels in your blood. This makes the medicine less effective at preventing dangerous blood clots.
Carbamazepine carries more major-labeled pairs than Apixaban
SPL source-record counts only. This page's band is moderate · classes on file: Carbamazepine (Anticonvulsant); Apixaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)).
Carbamazepine has 3 major-labeled pairs vs Apixaban's 0. This page itself is in the moderate band, not the major band.
3 major · 16 moderate · 110 minor · 129 total
- Other moderate peers for Carbamazepine
- Lithium
- Desmopressin
- Dronedarone
- Fluconazole
0 major · 9 moderate · 3 minor · 12 total
- Other moderate peers for Apixaban
- Clopidogrel
- Aspirin
- Warfarin
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.