What the FDA labels say about taking them together
Mirtazapine and phenelzine
Mirtazapine's FDA label of August 6, 2025 names phenelzine in its drug interactions section, and phenelzine's label names mirtazapine too.
Check it at the source: the mirtazapine FDA label on DailyMed (effective August 6, 2025, Organon LLC); the phenelzine FDA label on DailyMed (effective June 6, 2025, Parke-Davis Div of Pfizer Inc).
What does the mirtazapine label say about phenelzine?
Mirtazapine label, drug interactionsExamples; selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue
Source: FDA drug label (REMERON), Organon LLC, effective August 6, 2025 (SPL set 98ad1917-a094-44f5-a28f-a64a8cfcd887), via openFDA; the full label on DailyMed
What does the phenelzine label say about mirtazapine?
Phenelzine label, warningsA List of Dibenzazepine Derivative Drugs by Generic Name Follows: nortriptyline hydrochloride amitriptyline hydrochloride perphenazine and amitriptyline hydrochloride clomipramine hydrochloride desipramine hydrochloride imipramine hydrochloride doxepin carbamazepine cyclobenzaprine HCl amoxapine maprotiline HCl trimipramine maleate protriptyline HCl mirtazapine NARDIL should be used with caution in combination with antihypertensive drugs, including thiazide diuretics and β-blockers, since exaggerated hypotensive effects may result.
Source: FDA drug label (Nardil), Parke-Davis Div of Pfizer Inc, effective June 6, 2025 (SPL set 513a41d0-37d4-4355-8a6d-a2c643bce6fa), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Mirtazapine | Phenelzine | |
|---|---|---|
| Labeled for | Depression | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.063 per tablet 15 mg tablet | $0.586 per tablet 15 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once