Carbamazepine and Ranolazine Interaction
Drug interaction information between Carbamazepine and Ranolazine.
Carbamazepine and Ranolazine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Carbamazepine and Ranolazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine makes your body get rid of ranolazine too quickly, which prevents the medicine from working as it should.
FDA Label Information
CYP3A Inducers Do not use ranolazine with CYP3A inducers such as rifampin, rifabutin, rifapentine, phenobarbital, phenytoin, carbamazepine, and St.
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Risperidone major
- Lithium moderate
- Apixaban moderate
- Desmopressin moderate
Ranolazine Also Interacts With
- Ketoconazole major
- Clarithromycin major
- Rifampin major
- Phenytoin major
- Phenobarbital major
Frequently Asked Questions
What SPL severity band is on file for Carbamazepine + Ranolazine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Ranolazine's 31. In the major band specifically: Carbamazepine has 3 (also Nirmatrelvir/Ritonavir, Risperidone); Ranolazine has 12 (also Ketoconazole, Clarithromycin, Rifampin, Phenytoin).
What mechanism field is on file for Carbamazepine and Ranolazine?
Carbamazepine makes your body get rid of ranolazine too quickly, which prevents the medicine from working as it should.
Ranolazine carries more major-labeled pairs than Carbamazepine
SPL source-record counts only. This page's band is major · classes on file: Carbamazepine (Anticonvulsant); Ranolazine (Late Sodium Current Inhibitor (Antianginal)).
Ranolazine has 12 major-labeled pairs vs Carbamazepine's 3.
3 major · 16 moderate · 110 minor · 129 total
- Other major peers for Carbamazepine
- Nirmatrelvir/Ritonavir
- Risperidone
12 major · 7 moderate · 12 minor · 31 total
- Other major peers for Ranolazine
- Ketoconazole
- Clarithromycin
- Rifampin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.