Mirtazapine and Tranylcypromine Interaction
Drug interaction information between Mirtazapine and Tranylcypromine.
Mirtazapine and Tranylcypromine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Mirtazapine and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both work by raising serotonin levels in your system. Using them at the same time increases the risk of a serious condition called serotonin syndrome.
FDA Label Information
Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact The concomitant use of serotonergic drugs with mirtazapine increases the risk of serotonin syndrome.
Mirtazapine Also Interacts With
- Linezolid major
- Alprazolam moderate
- Diazepam moderate
- Phenelzine moderate
- Selegiline moderate
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Frequently Asked Questions
What SPL severity band is on file for Mirtazapine + Tranylcypromine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Mirtazapine's 29. In the moderate band specifically: Mirtazapine has 5 (also Alprazolam, Diazepam, Phenelzine, Selegiline); Tranylcypromine has 23 (also Buspirone, Cyclobenzaprine, Carbamazepine, Lithium).
What mechanism field is on file for Mirtazapine and Tranylcypromine?
These drugs both work by raising serotonin levels in your system. Using them at the same time increases the risk of a serious condition called serotonin syndrome.
Tranylcypromine carries more major-labeled pairs than Mirtazapine
SPL source-record counts only. This page's band is moderate · classes on file: Mirtazapine (Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Tranylcypromine has 7 major-labeled pairs vs Mirtazapine's 1. This page itself is in the moderate band, not the major band.
1 major · 5 moderate · 23 minor · 29 total
- Other moderate peers for Mirtazapine
- Alprazolam
- Diazepam
- Phenelzine
- Selegiline
7 major · 23 moderate · 12 minor · 42 total
- Other moderate peers for Tranylcypromine
- Buspirone
- Cyclobenzaprine
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.