Lovastatin and Digoxin Interaction
Drug interaction information between Lovastatin and Digoxin.
Lovastatin and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lovastatin and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking lovastatin does not change the levels of digoxin in your body.
FDA Label Information
Digoxin In patients with hypercholesterolemia, concomitant administration of lovastatin and digoxin resulted in no effect on digoxin plasma concentrations.
Lovastatin Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Lovastatin + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Lovastatin's 30. In the minor band specifically: Lovastatin has 11 (also Glipizide, Propranolol, Warfarin, Testosterone); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Lovastatin and Digoxin?
Taking lovastatin does not change the levels of digoxin in your body.
Digoxin's labeled portfolio outnumbers Lovastatin
SPL source-record counts only. This page's band is minor · classes on file: Lovastatin (HMG-CoA Reductase Inhibitor (Statin)); Digoxin (Cardiac Glycoside).
2 major · 17 moderate · 11 minor · 30 total
- Other minor peers for Lovastatin
- Glipizide
- Propranolol
- Warfarin
- Testosterone
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.