Lovastatin and Verapamil Interaction
Drug interaction information between Lovastatin and Verapamil.
Lovastatin and Verapamil have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lovastatin and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Verapamil slows down the process of removing lovastatin from your body. This can cause lovastatin to reach high levels that increase the risk of muscle injury.
FDA Label Information
Danazol, Diltiazem, Dronedarone or Verapamil The risk of myopathy/rhabdomyolysis is increased by concomitant administration of danazol, diltiazem, dronedarone or verapamil particularly with higher doses of lovastatin (see WARNINGS , Myopathy/Rhabdomyolysis ; CLINICAL PHARMACOLOGY , Pharmacokinetics ).
Lovastatin Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Cyclosporine moderate
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Lovastatin + Verapamil?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Lovastatin's 30. In the moderate band specifically: Lovastatin has 17 (also Spironolactone, Ketoconazole, Cyclosporine, Erythromycin); Verapamil has 6 (also Clarithromycin, Metoprolol, Midazolam, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Lovastatin and Verapamil?
Verapamil slows down the process of removing lovastatin from your body. This can cause lovastatin to reach high levels that increase the risk of muscle injury.
Verapamil carries more major-labeled pairs than Lovastatin
SPL source-record counts only. This page's band is moderate · classes on file: Lovastatin (HMG-CoA Reductase Inhibitor (Statin)); Verapamil (Calcium Channel Blocker).
Verapamil has 4 major-labeled pairs vs Lovastatin's 2. This page itself is in the moderate band, not the major band.
2 major · 17 moderate · 11 minor · 30 total
- Other moderate peers for Lovastatin
- Spironolactone
- Ketoconazole
- Cyclosporine
- Erythromycin
4 major · 6 moderate · 47 minor · 57 total
- Other moderate peers for Verapamil
- Clarithromycin
- Metoprolol
- Midazolam
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.