What the FDA labels say about taking them together
Ketoconazole and lovastatin
Lovastatin's FDA label of May 6, 2026 names ketoconazole in its contraindications section; the ketoconazole label PlainMeds reads does not name lovastatin. The lovastatin label: “Concomitant administration with strong CYP3A4 inhibitors.”
Check it at the source: the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the lovastatin FDA label on DailyMed (effective May 6, 2026, Lupin Pharmaceuticals, Inc.).
What does the ketoconazole label say about lovastatin?
Ketoconazole's label (effective January 28, 2026) does not name lovastatin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
What does the lovastatin label say about ketoconazole?
Lovastatin label, contraindicationsConcomitant administration with strong CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, posaconazole, voriconazole, HIV protease inhibitors, boceprevir, telaprevir, erythromycin, clarithromycin, telithromycin, nefazodone, and cobicistat-containing products) (see WARNINGS, Myopathy/Rhabdomyolysis ).
Lovastatin label, warningsThese include itraconazole, ketoconazole, posaconazole, voriconazole, the macrolide antibiotics erythromycin and clarithromycin, the ketolide antibiotic telithromycin, HIV protease inhibitors, boceprevir, telaprevir, the antidepressant nefazodone, or cobicistat-containing products.
Source: FDA drug label (Lovastatin), Lupin Pharmaceuticals, Inc., effective May 6, 2026 (SPL set df7ddf4f-d569-431e-81f1-9129d7043150), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketoconazole | Lovastatin | |
|---|---|---|
| Labeled for | Fungal infections | High cholesterol, Heart attack and coronary artery disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.249 per gram 2% cream | $0.0436 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once