digoxin vs lovastatin
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Side-by-side comparison of digoxin and lovastatin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Digoxin In patients with hypercholesterolemia, concomitant administration of lovastatin and digoxin resulted in no effect on digoxin plasma concentrations.
Lanoxin
Mevacor, Altoprev
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Lovastatin is a medicine that helps lower cholesterol levels in your blood. It belongs to a class of drugs called statins.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Lovastatin is used to lower cholesterol and reduce the risk of heart problems. It can help prevent heart attacks, unstable angina (chest pain), and the need for procedures to open blocked arteries. It's also used to slow down the hardening of arteries in people who already have heart disease. Lovastatin can also be used in children 10-17 years of age with high cholesterol due to genetic causes.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Lovastatin works by blocking a substance your body needs to make cholesterol. This helps to lower the amount of cholesterol in your blood. Lowering cholesterol helps to prevent heart disease and stroke.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Abdominal pain
- • Constipation
- • Diarrhea
- • Gas
- • Nausea
- Dyspnoea 6,065
- Nausea 4,754
- Dizziness 4,439
- Fatigue 4,175
- Atrial Fibrillation 3,974
- Fatigue 1,518
- Nausea 1,396
- Diarrhoea 1,251
- Dyspnoea 1,209
- Dizziness 1,147
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
Lovastatin can cause muscle problems, including muscle breakdown (rhabdomyolysis), which can lead to kidney damage. The risk is higher if you take certain other medicines with lovastatin. You should not take lovastatin if you have liver problems or are pregnant or breastfeeding.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
You should not take lovastatin if you are pregnant or breastfeeding. It can harm your unborn baby. If you are a woman who could become pregnant, use effective birth control while taking lovastatin.
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How to Read This digoxin vs lovastatin Comparison
digoxin is classified in the Cardiac Glycoside drug class, while lovastatin sits within the HMG-CoA Reductase Inhibitor (Statin) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,407 submissions while lovastatin has 6,521. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to taking lovastatin does not change the levels of digoxin in your body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for digoxin or lovastatin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.