Lovastatin and Spironolactone Interaction
Drug interaction information between Lovastatin and Spironolactone.
Lovastatin and Spironolactone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lovastatin and Spironolactone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can lower the levels of natural hormones in your body. Using them together might interfere with how your hormones work.
FDA Label Information
Caution should also be exercised if an HMG-CoA reductase inhibitor or other agent used to lower cholesterol levels is administered to patients also receiving other drugs (e.g., spironolactone, cimetidine) that may decrease the levels or activity of endogenous steroid hormones.
Lovastatin Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
- Cyclosporine moderate
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Lovastatin + Spironolactone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lovastatin has 30 labeled pairs on file vs Spironolactone's 23. In the moderate band specifically: Lovastatin has 17 (also Ketoconazole, Verapamil, Cyclosporine, Erythromycin); Spironolactone has 9 (also Lithium, Trimethoprim, Heparin, Amlodipine/Benazepril).
What mechanism field is on file for Lovastatin and Spironolactone?
Both of these medications can lower the levels of natural hormones in your body. Using them together might interfere with how your hormones work.
Lovastatin carries more major-labeled pairs than Spironolactone
SPL source-record counts only. This page's band is moderate · classes on file: Lovastatin (HMG-CoA Reductase Inhibitor (Statin)); Spironolactone (Potassium-Sparing Diuretic / Aldosterone Antagonist).
Lovastatin has 2 major-labeled pairs vs Spironolactone's 0. This page itself is in the moderate band, not the major band.
2 major · 17 moderate · 11 minor · 30 total
- Other moderate peers for Lovastatin
- Ketoconazole
- Verapamil
- Cyclosporine
- Erythromycin
0 major · 9 moderate · 14 minor · 23 total
- Other moderate peers for Spironolactone
- Lithium
- Trimethoprim
- Heparin
- Amlodipine/Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.