Lovastatin and Darunavir Interaction
Drug interaction information between Lovastatin and Darunavir.
Lovastatin and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Lovastatin and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir raises the level of lovastatin in the blood, which can lead to severe muscle breakdown.
FDA Label Information
Lipid Modifying Agents: HMG-CoA reductase inhibitors: lovastatin, simvastatin ↑ lovastatin ↑ simvastatin Co-administration is contraindicated due to potential for serious reactions such as myopathy including rhabdomyolysis.
Lovastatin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
- Cyclosporine moderate
Darunavir Also Interacts With
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Lovastatin + Darunavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Lovastatin's 30. In the major band specifically: Lovastatin has 2 (also Nirmatrelvir/Ritonavir); Darunavir has 15 (also Sildenafil, Lurasidone, Pimozide, Midazolam).
What mechanism field is on file for Lovastatin and Darunavir?
Darunavir raises the level of lovastatin in the blood, which can lead to severe muscle breakdown.
Darunavir carries more major-labeled pairs than Lovastatin
SPL source-record counts only. This page's band is major · classes on file: Lovastatin (HMG-CoA Reductase Inhibitor (Statin)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Lovastatin's 2.
2 major · 17 moderate · 11 minor · 30 total
- Other major peers for Lovastatin
- Nirmatrelvir/Ritonavir
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Sildenafil
- Lurasidone
- Pimozide
- Midazolam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.