Levofloxacin and Digoxin Interaction
Drug interaction information between Levofloxacin and Digoxin.
Levofloxacin and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Levofloxacin and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not interfere with each other's levels in the blood or how the body handles them.
FDA Label Information
7.7 Digoxin No significant effect of levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for digoxin was detected in a clinical study involving healthy volunteers. Levofloxacin absorption and disposition kinetics were similar in the presence or absence of digoxin. Therefore, no dosage adjustment for levofloxacin or digoxin is required when administered concomitantly.
Levofloxacin Also Interacts With
- Probenecid major
- Cimetidine major
- Theophylline moderate
- Warfarin minor
- Cyclosporine minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Levofloxacin + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Levofloxacin's 8. In the minor band specifically: Levofloxacin has 5 (also Warfarin, Cyclosporine, Sucralfate, Zinc Sulfate); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Levofloxacin and Digoxin?
These two drugs do not interfere with each other's levels in the blood or how the body handles them.
Digoxin's labeled portfolio outnumbers Levofloxacin
SPL source-record counts only. This page's band is minor · classes on file: Levofloxacin (Fluoroquinolone Antibiotic); Digoxin (Cardiac Glycoside).
2 major · 1 moderate · 5 minor · 8 total
- Other minor peers for Levofloxacin
- Warfarin
- Cyclosporine
- Sucralfate
- Zinc Sulfate
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.