Levofloxacin and Probenecid Interaction
Drug interaction information between Levofloxacin and Probenecid.
Levofloxacin and Probenecid have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Levofloxacin and Probenecid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid slows down the kidneys' ability to remove levofloxacin, which keeps the antibiotic in your system for a longer time.
FDA Label Information
7.8 Probenecid and Cimetidine No significant effect of probenecid or cimetidine on the Cmax of levofloxacin was observed in a clinical study involving healthy volunteers. The AUC and t 1/2 of levofloxacin were higher while CL/F and CLR were lower during concomitant treatment of levofloxacin with probenecid or cimetidine compared to levofloxacin alone. However, these changes do not warrant dosage adjustment for levofloxacin when probenecid or cimetidine is co-administered.
Levofloxacin Also Interacts With
- Cimetidine major
- Theophylline moderate
- Warfarin minor
- Cyclosporine minor
- Digoxin minor
Probenecid Also Interacts With
- Ketorolac major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
- Cefuroxime moderate
Frequently Asked Questions
What SPL severity band is on file for Levofloxacin + Probenecid?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Levofloxacin's 8. In the major band specifically: Levofloxacin has 2 (also Cimetidine); Probenecid has 2 (also Ketorolac).
What mechanism field is on file for Levofloxacin and Probenecid?
Probenecid slows down the kidneys' ability to remove levofloxacin, which keeps the antibiotic in your system for a longer time.
Probenecid's labeled portfolio outnumbers Levofloxacin
SPL source-record counts only. This page's band is major · classes on file: Levofloxacin (Fluoroquinolone Antibiotic); Probenecid (Uricosuric Agent).
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.