Levofloxacin and Sucralfate Interaction
Drug interaction information between Levofloxacin and Sucralfate.
Levofloxacin and Sucralfate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Levofloxacin and Sucralfate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sucralfate attaches to the medicine in your stomach and prevents it from being absorbed into your body. This means the antibiotic might not work well enough to kill the bacteria.
FDA Label Information
Monitor prothrombin time, INR and watch for bleeding (7.2) Antidiabetic agents Carefully monitor blood glucose (5.13, 7.3) 7.1 Chelation Agents: Antacids, Sucralfate, Metal Cations, Multivitamins While the chelation by divalent cations is less marked than with other fluoroquinolones, concurrent administration of levofloxacin tablets with antacids containing magnesium, or aluminum, as well as sucralfate, metal cations such as iron, and multivitamin preparations with zinc may interfere with the gastrointestinal absorption of levofloxacin, resulting in systemic levels considerably lower than...
Levofloxacin Also Interacts With
- Probenecid major
- Cimetidine major
- Theophylline moderate
- Warfarin minor
- Cyclosporine minor
Sucralfate Also Interacts With
- Theophylline major
- Naproxen moderate
- Warfarin minor
- Ketoconazole minor
- Ciprofloxacin minor
Frequently Asked Questions
What SPL severity band is on file for Levofloxacin + Sucralfate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sucralfate has 20 labeled pairs on file vs Levofloxacin's 8. In the minor band specifically: Levofloxacin has 5 (also Warfarin, Cyclosporine, Digoxin, Zinc Sulfate); Sucralfate has 18 (also Warfarin, Ketoconazole, Ciprofloxacin, Ofloxacin).
What mechanism field is on file for Levofloxacin and Sucralfate?
Sucralfate attaches to the medicine in your stomach and prevents it from being absorbed into your body. This means the antibiotic might not work well enough to kill the bacteria.
Levofloxacin carries more major-labeled pairs than Sucralfate
SPL source-record counts only. This page's band is minor · classes on file: Levofloxacin (Fluoroquinolone Antibiotic); Sucralfate (Mucosal Protective Agent).
Levofloxacin has 2 major-labeled pairs vs Sucralfate's 1. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 5 minor · 8 total
- Other minor peers for Levofloxacin
- Warfarin
- Cyclosporine
- Digoxin
- Zinc Sulfate
1 major · 1 moderate · 18 minor · 20 total
- Other minor peers for Sucralfate
- Warfarin
- Ketoconazole
- Ciprofloxacin
- Ofloxacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.