Levofloxacin and Cyclosporine Interaction
Drug interaction information between Levofloxacin and Cyclosporine.
Levofloxacin and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Levofloxacin and Cyclosporine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Levofloxacin may slightly change how your body processes cyclosporine, and similar drugs have been known to raise cyclosporine levels in the blood.
What To Do
Your doctor may need to monitor your cyclosporine blood levels to ensure they stay in a safe range.
FDA Label Information
7.6 Cyclosporine No significant effect of levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for cyclosporine was detected in a clinical study involving healthy volunteers. However, elevated serum levels of cyclosporine have been reported in the patient population when co-administered with some other fluoroquinolones. Levofloxacin C max and k e were slightly lower while T max and t1/2 were slightly longer in the presence of cyclosporine than those observed in other studies without concomitant medication.
Levofloxacin Also Interacts With
- Probenecid major
- Cimetidine major
- Theophylline moderate
- Warfarin minor
- Digoxin minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
Can I take Levofloxacin and Cyclosporine together?
This is a minor interaction. Your doctor may need to monitor your cyclosporine blood levels to ensure they stay in a safe range.
How serious is the interaction between Levofloxacin and Cyclosporine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Levofloxacin and Cyclosporine interact?
Levofloxacin may slightly change how your body processes cyclosporine, and similar drugs have been known to raise cyclosporine levels in the blood.
Understanding the Levofloxacin and Cyclosporine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Levofloxacin belongs to the Fluoroquinolone Antibiotic class and Cyclosporine belongs to the Calcineurin Inhibitor (Immunosuppressant) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Levofloxacin may slightly change how your body processes cyclosporine, and similar drugs have been known to raise cyclosporine levels in the blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Levofloxacin has 8 total documented interactions on file in this dataset, and Cyclosporine has 89. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to monitor your cyclosporine blood levels to ensure they stay in a safe range. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Levofloxacin or Cyclosporine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.