Levofloxacin and Cyclosporine Interaction
Drug interaction information between Levofloxacin and Cyclosporine.
Levofloxacin and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Levofloxacin and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Levofloxacin may slightly change how your body processes cyclosporine, and similar drugs have been known to raise cyclosporine levels in the blood.
FDA Label Information
7.6 Cyclosporine No significant effect of levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for cyclosporine was detected in a clinical study involving healthy volunteers. However, elevated serum levels of cyclosporine have been reported in the patient population when co-administered with some other fluoroquinolones. Levofloxacin C max and k e were slightly lower while T max and t1/2 were slightly longer in the presence of cyclosporine than those observed in other studies without concomitant medication.
Levofloxacin Also Interacts With
- Probenecid major
- Cimetidine major
- Theophylline moderate
- Warfarin minor
- Digoxin minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Levofloxacin + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Levofloxacin's 8. In the minor band specifically: Levofloxacin has 5 (also Warfarin, Digoxin, Sucralfate, Zinc Sulfate); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Levofloxacin and Cyclosporine?
Levofloxacin may slightly change how your body processes cyclosporine, and similar drugs have been known to raise cyclosporine levels in the blood.
Cyclosporine carries more major-labeled pairs than Levofloxacin
SPL source-record counts only. This page's band is minor · classes on file: Levofloxacin (Fluoroquinolone Antibiotic); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Levofloxacin's 2. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 5 minor · 8 total
- Other minor peers for Levofloxacin
- Warfarin
- Digoxin
- Sucralfate
- Zinc Sulfate
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.