Levofloxacin and Zinc Sulfate Interaction
Drug interaction information between Levofloxacin and Zinc Sulfate.
Levofloxacin and Zinc Sulfate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Levofloxacin and Zinc Sulfate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Zinc binds to the antibiotic in your digestive system, which stops the medicine from entering your blood. This can make the treatment less effective at fighting your infection.
FDA Label Information
Monitor prothrombin time, INR and watch for bleeding (7.2) Antidiabetic agents Carefully monitor blood glucose (5.13, 7.3) 7.1 Chelation Agents: Antacids, Sucralfate, Metal Cations, Multivitamins While the chelation by divalent cations is less marked than with other fluoroquinolones, concurrent administration of levofloxacin tablets with antacids containing magnesium, or aluminum, as well as sucralfate, metal cations such as iron, and multivitamin preparations with zinc may interfere with the gastrointestinal absorption of levofloxacin, resulting in systemic levels considerably lower than...
Levofloxacin Also Interacts With
- Probenecid major
- Cimetidine major
- Theophylline moderate
- Warfarin minor
- Cyclosporine minor
Zinc Sulfate Also Interacts With
- Baloxavir Marboxil moderate
- Delafloxacin minor
- Moxifloxacin minor
- Tetracycline minor
Frequently Asked Questions
What SPL severity band is on file for Levofloxacin + Zinc Sulfate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Levofloxacin has 8 labeled pairs on file vs Zinc Sulfate's 5. In the minor band specifically: Levofloxacin has 5 (also Warfarin, Cyclosporine, Digoxin, Sucralfate); Zinc Sulfate has 4 (also Delafloxacin, Moxifloxacin, Tetracycline).
What mechanism field is on file for Levofloxacin and Zinc Sulfate?
Zinc binds to the antibiotic in your digestive system, which stops the medicine from entering your blood. This can make the treatment less effective at fighting your infection.
Levofloxacin carries more major-labeled pairs than Zinc Sulfate
SPL source-record counts only. This page's band is minor · classes on file: Levofloxacin (Fluoroquinolone Antibiotic); Zinc Sulfate (Mineral Supplement).
Levofloxacin has 2 major-labeled pairs vs Zinc Sulfate's 0. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 5 minor · 8 total
- Other minor peers for Levofloxacin
- Warfarin
- Cyclosporine
- Digoxin
- Sucralfate
0 major · 1 moderate · 4 minor · 5 total
- Other minor peers for Zinc Sulfate
- Delafloxacin
- Moxifloxacin
- Tetracycline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.