digoxin vs levofloxacin
Side-by-side comparison of digoxin and levofloxacin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.7 Digoxin No significant effect of levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for digoxin was detected in a clinical study involving healthy volunteers. Levofloxacin absorption and disposition kinetics were similar in the presence or absence of digoxin. Therefore, no dosage adjustment for levofloxacin or digoxin is required when administered concomitantly.
Recommendation: No dosage adjustments are required when taking these two medications at the same time.
Lanoxin
Levaquin
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Levofloxacin is an antibiotic that fights bacteria in your body. It is used to treat different types of infections.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Levofloxacin treats infections like pneumonia, skin infections, prostate infections, and urinary tract infections. It can also treat anthrax after exposure and plague. This medicine should only be used for certain infections when other options won't work.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Levofloxacin belongs to a class of drugs called fluoroquinolones. It works by stopping bacteria from multiplying. This helps your body fight off the infection.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Nausea
- • Headache
- • Diarrhea
- • Trouble sleeping
- • Constipation
- Shortness of breath 6,062
- Feeling sick to your stomach 4,747
- Feeling lightheaded or unsteady 4,442
- Feeling very tired 4,174
- Irregular heartbeat 3,972
- Dyspnoea 2,949
- Pneumonia 2,862
- Nausea 2,791
- Pyrexia 2,725
- Fatigue 2,658
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
This drug has serious warnings. Levofloxacin can cause tendon problems, nerve damage, and central nervous system effects. It can also make muscle weakness worse if you have myasthenia gravis. If you have any of these side effects, stop taking the medicine and call your doctor right away. Only use this medicine if you have no other treatment options for uncomplicated urinary tract infections, bronchitis, or sinusitis.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
Tell your doctor if you are pregnant or plan to become pregnant. Levofloxacin should only be used during pregnancy if the benefit outweighs the risk to the baby. It may pass into breast milk, so talk to your doctor about breastfeeding.
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How to Read This digoxin vs levofloxacin Comparison
digoxin is classified in the Cardiac Glycoside drug class, while levofloxacin sits within the Fluoroquinolone Antibiotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,397 submissions while levofloxacin has 13,985. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these two drugs do not interfere with each other's levels in the blood or how the body handles them.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between digoxin and levofloxacin - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.