Levofloxacin and Warfarin Interaction
Drug interaction information between Levofloxacin and Warfarin.
Levofloxacin and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Levofloxacin and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Levofloxacin can increase the blood-thinning effects of warfarin, which may increase the risk of bleeding.
FDA Label Information
(2.4, 7.1) Warfarin Effect may be enhanced. 7.2 Warfarin No significant effect of levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for R- and S- warfarin was detected in a clinical study involving healthy volunteers. Similarly, no apparent effect of warfarin on levofloxacin absorption and disposition was observed.
Levofloxacin Also Interacts With
- Probenecid major
- Cimetidine major
- Theophylline moderate
- Cyclosporine minor
- Digoxin minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Levofloxacin + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Levofloxacin's 8. In the minor band specifically: Levofloxacin has 5 (also Cyclosporine, Digoxin, Sucralfate, Zinc Sulfate); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Levofloxacin and Warfarin?
Levofloxacin can increase the blood-thinning effects of warfarin, which may increase the risk of bleeding.
Warfarin's labeled portfolio outnumbers Levofloxacin
SPL source-record counts only. This page's band is minor · classes on file: Levofloxacin (Fluoroquinolone Antibiotic); Warfarin (Vitamin K Antagonist (Anticoagulant)).
2 major · 1 moderate · 5 minor · 8 total
- Other minor peers for Levofloxacin
- Cyclosporine
- Digoxin
- Sucralfate
- Zinc Sulfate
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.