Ledipasvir/Sofosbuvir and Pravastatin Interaction
Drug interaction information between Ledipasvir/Sofosbuvir and Pravastatin.
Ledipasvir/Sofosbuvir and Pravastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ledipasvir/Sofosbuvir and Pravastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not interfere with each other when they are taken at the same time.
FDA Label Information
7.3 Drugs without Clinically Significant Interactions with HARVONI Based on drug interaction studies conducted with the components of HARVONI (ledipasvir or sofosbuvir) or HARVONI, no clinically significant drug interactions have been either observed or are expected when HARVONI is used with the following drugs [see Clinical Pharmacology (12.3) ]: abacavir, atazanavir/ritonavir, cyclosporine, darunavir/ritonavir, dolutegravir, efavirenz, elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide, emtricitabine, lamivudine, methadone, midazolam, oral contraceptives, pravastatin,...
Ledipasvir/Sofosbuvir Also Interacts With
- Atorvastatin moderate
- Rifampin moderate
- Amiodarone moderate
- Rosuvastatin moderate
- Rosuvastatin/Ezetimibe moderate
Pravastatin Also Interacts With
- Cyclosporine moderate
- Erythromycin moderate
- Clarithromycin moderate
- Colchicine moderate
- Gemfibrozil moderate
Frequently Asked Questions
What SPL severity band is on file for Ledipasvir/Sofosbuvir + Pravastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ledipasvir/Sofosbuvir has 22 labeled pairs on file vs Pravastatin's 16. In the minor band specifically: Ledipasvir/Sofosbuvir has 17 (also Omeprazole, Warfarin, Verapamil, Cyclosporine); Pravastatin has 7 (also Azithromycin, Darunavir, Diltiazem, Efavirenz).
What mechanism field is on file for Ledipasvir/Sofosbuvir and Pravastatin?
These two drugs do not interfere with each other when they are taken at the same time.
Ledipasvir/Sofosbuvir's labeled portfolio outnumbers Pravastatin
SPL source-record counts only. This page's band is minor · classes on file: Ledipasvir/Sofosbuvir (NS5A/NS5B Inhibitor (HCV)); Pravastatin (HMG-CoA Reductase Inhibitor (Statin)).
0 major · 5 moderate · 17 minor · 22 total
- Other minor peers for Ledipasvir/Sofosbuvir
- Omeprazole
- Warfarin
- Verapamil
- Cyclosporine
0 major · 9 moderate · 7 minor · 16 total
- Other minor peers for Pravastatin
- Azithromycin
- Darunavir
- Diltiazem
- Efavirenz
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.