Ledipasvir/Sofosbuvir and Rifampin Interaction
Drug interaction information between Ledipasvir/Sofosbuvir and Rifampin.
Ledipasvir/Sofosbuvir and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ledipasvir/Sofosbuvir and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin reduces the levels of Harvoni in your body, which can prevent the medicine from treating your infection properly.
FDA Label Information
( 5.2 , 6.2 , 7.2 ) P-gp inducers (e.g., rifampin, St. P-gp inducers (e.g., rifampin, St. Antimycobacterials: rifabutin rifampin rifapentine ↓ ledipasvir ↓ sofosbuvir Coadministration of HARVONI with rifampin, rifabutin, or rifapentine is not recommended [see Warnings and Precautions (5.3) ].
Ledipasvir/Sofosbuvir Also Interacts With
- Atorvastatin moderate
- Amiodarone moderate
- Rosuvastatin moderate
- Rosuvastatin/Ezetimibe moderate
- Omeprazole minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Ledipasvir/Sofosbuvir + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Ledipasvir/Sofosbuvir's 22. In the moderate band specifically: Ledipasvir/Sofosbuvir has 5 (also Atorvastatin, Amiodarone, Rosuvastatin, Rosuvastatin/Ezetimibe); Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Ledipasvir/Sofosbuvir and Rifampin?
Rifampin reduces the levels of Harvoni in your body, which can prevent the medicine from treating your infection properly.
Rifampin carries more major-labeled pairs than Ledipasvir/Sofosbuvir
SPL source-record counts only. This page's band is moderate · classes on file: Ledipasvir/Sofosbuvir (NS5A/NS5B Inhibitor (HCV)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Ledipasvir/Sofosbuvir's 0. This page itself is in the moderate band, not the major band.
0 major · 5 moderate · 17 minor · 22 total
- Other moderate peers for Ledipasvir/Sofosbuvir
- Atorvastatin
- Amiodarone
- Rosuvastatin
- Rosuvastatin/Ezetimibe
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.