Ledipasvir/Sofosbuvir and Rosuvastatin/Ezetimibe Interaction
Drug interaction information between Ledipasvir/Sofosbuvir and Rosuvastatin/Ezetimibe.
Ledipasvir/Sofosbuvir and Rosuvastatin/Ezetimibe have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ledipasvir/Sofosbuvir and Rosuvastatin/Ezetimibe. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications can cause rosuvastatin to build up in your system, which increases the risk of harmful side effects.
FDA Label Information
Intervention: Sofosbuvir/velpatasvir/voxilaprevir Ledipasvir/sofosbuvir Avoid concomitant use with rosuvastatin.
Ledipasvir/Sofosbuvir Also Interacts With
- Atorvastatin moderate
- Rifampin moderate
- Amiodarone moderate
- Rosuvastatin moderate
- Omeprazole minor
Rosuvastatin/Ezetimibe Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Rosuvastatin moderate
- Cyclosporine moderate
Frequently Asked Questions
What SPL severity band is on file for Ledipasvir/Sofosbuvir + Rosuvastatin/Ezetimibe?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ledipasvir/Sofosbuvir has 22 labeled pairs on file vs Rosuvastatin/Ezetimibe's 12. In the moderate band specifically: Ledipasvir/Sofosbuvir has 5 (also Atorvastatin, Rifampin, Amiodarone, Rosuvastatin); Rosuvastatin/Ezetimibe has 7 (also Rosuvastatin, Cyclosporine, Colchicine, Gemfibrozil).
What mechanism field is on file for Ledipasvir/Sofosbuvir and Rosuvastatin/Ezetimibe?
These medications can cause rosuvastatin to build up in your system, which increases the risk of harmful side effects.
Rosuvastatin/Ezetimibe carries more major-labeled pairs than Ledipasvir/Sofosbuvir
SPL source-record counts only. This page's band is moderate · classes on file: Ledipasvir/Sofosbuvir (NS5A/NS5B Inhibitor (HCV)); Rosuvastatin/Ezetimibe (Statin / Cholesterol Absorption Inhibitor).
Rosuvastatin/Ezetimibe has 3 major-labeled pairs vs Ledipasvir/Sofosbuvir's 0. This page itself is in the moderate band, not the major band.
0 major · 5 moderate · 17 minor · 22 total
- Other moderate peers for Ledipasvir/Sofosbuvir
- Atorvastatin
- Rifampin
- Amiodarone
- Rosuvastatin
3 major · 7 moderate · 2 minor · 12 total
- Other moderate peers for Rosuvastatin/Ezetimibe
- Rosuvastatin
- Cyclosporine
- Colchicine
- Gemfibrozil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.