What the FDA labels say about taking them together
Ledipasvir/sofosbuvir and omeprazole
Ledipasvir/sofosbuvir's FDA label of December 26, 2024 names omeprazole in its drug interactions section; the omeprazole labels PlainMeds reads (2) do not name ledipasvir/sofosbuvir.
Check it at the source: the ledipasvir/sofosbuvir FDA label on DailyMed (effective December 26, 2024, Gilead Sciences, Inc); the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp).
What does the ledipasvir/sofosbuvir label say about omeprazole?
Ledipasvir/sofosbuvir label, drug interactionsConcomitant Drug Class/Drug Name: Proton-pump inhibitors (e.g., omeprazole); Effect on Concentration ↓ = decrease, ↑ = increase: ↓ ledipasvir; Clinical Comment: Proton-pump inhibitor doses comparable to omeprazole 20 mg or lower can be administered simultaneously with HARVONI under fasted conditions.
Source: FDA drug label (Harvoni), Gilead Sciences, Inc, effective December 26, 2024 (SPL set f4ec77e4-bae8-4db0-b3d5-bde09c5fa075), via openFDA; the full label on DailyMed
What does the omeprazole label say about ledipasvir/sofosbuvir?
Omeprazole's label (effective April 22, 2024) and its 1 other brand-application label do not name ledipasvir/sofosbuvir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ledipasvir/sofosbuvir | Omeprazole | |
|---|---|---|
| Labeled for | Hepatitis C | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.0295 per capsule 20 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once