Ledipasvir/Sofosbuvir and Omeprazole Interaction
Drug interaction information between Ledipasvir/Sofosbuvir and Omeprazole.
Ledipasvir/Sofosbuvir and Omeprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ledipasvir/Sofosbuvir and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Omeprazole lowers stomach acid, which can affect how well the body takes in the hepatitis C medicine.
FDA Label Information
Proton-pump inhibitors (e.g., omeprazole) Proton-pump inhibitor doses comparable to omeprazole 20 mg or lower can be administered simultaneously with HARVONI under fasted conditions.
Ledipasvir/Sofosbuvir Also Interacts With
- Atorvastatin moderate
- Rifampin moderate
- Amiodarone moderate
- Rosuvastatin moderate
- Rosuvastatin/Ezetimibe moderate
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Frequently Asked Questions
What SPL severity band is on file for Ledipasvir/Sofosbuvir + Omeprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Omeprazole has 27 labeled pairs on file vs Ledipasvir/Sofosbuvir's 22. In the minor band specifically: Ledipasvir/Sofosbuvir has 17 (also Pravastatin, Warfarin, Verapamil, Cyclosporine); Omeprazole has 22 (also Aripiprazole, Atomoxetine, Brexpiprazole, Carbamazepine).
What mechanism field is on file for Ledipasvir/Sofosbuvir and Omeprazole?
Omeprazole lowers stomach acid, which can affect how well the body takes in the hepatitis C medicine.
Omeprazole carries more major-labeled pairs than Ledipasvir/Sofosbuvir
SPL source-record counts only. This page's band is minor · classes on file: Ledipasvir/Sofosbuvir (NS5A/NS5B Inhibitor (HCV)); Omeprazole (Proton Pump Inhibitor (PPI)).
Omeprazole has 1 major-labeled pair vs Ledipasvir/Sofosbuvir's 0. This page itself is in the minor band, not the major band.
0 major · 5 moderate · 17 minor · 22 total
- Other minor peers for Ledipasvir/Sofosbuvir
- Pravastatin
- Warfarin
- Verapamil
- Cyclosporine
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Aripiprazole
- Atomoxetine
- Brexpiprazole
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.