Ledipasvir/Sofosbuvir and Rosuvastatin Interaction
Drug interaction information between Ledipasvir/Sofosbuvir and Rosuvastatin.
Ledipasvir/Sofosbuvir and Rosuvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ledipasvir/Sofosbuvir and Rosuvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications can raise the levels of rosuvastatin in your blood to unsafe levels. This increases your risk of developing serious muscle problems.
FDA Label Information
Intervention: Sofosbuvir/velpatasvir/voxilaprevir Ledipasvir/sofosbuvir Avoid concomitant use with rosuvastatin.
Ledipasvir/Sofosbuvir Also Interacts With
- Atorvastatin moderate
- Rifampin moderate
- Amiodarone moderate
- Rosuvastatin/Ezetimibe moderate
- Omeprazole minor
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Ledipasvir/Sofosbuvir + Rosuvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ledipasvir/Sofosbuvir has 22 labeled pairs on file vs Rosuvastatin's 21. In the moderate band specifically: Ledipasvir/Sofosbuvir has 5 (also Atorvastatin, Rifampin, Amiodarone, Rosuvastatin/Ezetimibe); Rosuvastatin has 8 (also Cyclosporine, Colchicine, Gemfibrozil, Niacin).
What mechanism field is on file for Ledipasvir/Sofosbuvir and Rosuvastatin?
These medications can raise the levels of rosuvastatin in your blood to unsafe levels. This increases your risk of developing serious muscle problems.
Rosuvastatin carries more major-labeled pairs than Ledipasvir/Sofosbuvir
SPL source-record counts only. This page's band is moderate · classes on file: Ledipasvir/Sofosbuvir (NS5A/NS5B Inhibitor (HCV)); Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Rosuvastatin has 3 major-labeled pairs vs Ledipasvir/Sofosbuvir's 0. This page itself is in the moderate band, not the major band.
0 major · 5 moderate · 17 minor · 22 total
- Other moderate peers for Ledipasvir/Sofosbuvir
- Atorvastatin
- Rifampin
- Amiodarone
- Rosuvastatin/Ezetimibe
3 major · 8 moderate · 10 minor · 21 total
- Other moderate peers for Rosuvastatin
- Cyclosporine
- Colchicine
- Gemfibrozil
- Niacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.